Package: geneXtendeR
Type: Package
Version: 1.35.0
Title: Optimized Functional Annotation Of ChIP-seq Data
Description: geneXtendeR optimizes the functional annotation of ChIP-seq peaks by exploring relative differences in annotating ChIP-seq peak sets to variable-length gene bodies.  In contrast to prior techniques, geneXtendeR considers peak annotations beyond just the closest gene, allowing users to see peak summary statistics for the first-closest gene, second-closest gene, ..., n-closest gene whilst ranking the output according to biologically relevant events and iteratively comparing the fidelity of peak-to-gene overlap across a user-defined range of upstream and downstream extensions on the original boundaries of each gene's coordinates.  Since different ChIP-seq peak callers produce different differentially enriched peaks with a large variance in peak length distribution and total peak count, annotating peak lists with their nearest genes can often be a noisy process.  As such, the goal of geneXtendeR is to robustly link differentially enriched peaks with their respective genes, thereby aiding experimental follow-up and validation in designing primers for a set of prospective gene candidates during qPCR.
Authors@R: c(
        person("Bohdan", "Khomtchouk", email = "khomtchoukmed@gmail.com", role = c("aut", "cre")), 
        person("William", "Koehler", email = "williamk03hler@gmail.com", role = c("aut"))
            )
Maintainer: Bohdan Khomtchouk <khomtchoukmed@gmail.com>
URL: https://github.com/Bohdan-Khomtchouk/geneXtendeR
BugReports: https://github.com/Bohdan-Khomtchouk/geneXtendeR/issues
Depends: rtracklayer, GO.db, R (>= 3.5.0)
Imports: data.table, dplyr, graphics, networkD3, RColorBrewer,
        SnowballC, tm, utils, wordcloud, AnnotationDbi, BiocStyle,
        org.Rn.eg.db
Suggests: knitr, rmarkdown, testthat, org.Ag.eg.db, org.Bt.eg.db,
        org.Ce.eg.db, org.Cf.eg.db, org.Dm.eg.db, org.Dr.eg.db,
        org.Gg.eg.db, org.Hs.eg.db, org.Mm.eg.db, org.Pt.eg.db,
        org.Sc.sgd.db, org.Ss.eg.db, org.Xl.eg.db, rtracklayer
VignetteBuilder: knitr
License: GPL (>= 3)
LazyData: TRUE
biocViews: ChIPSeq, Genetics, Annotation, GenomeAnnotation,
        DifferentialPeakCalling, Coverage, PeakDetection, ChipOnChip,
        HistoneModification, DataImport, NaturalLanguageProcessing,
        Visualization, GO, Software
RoxygenNote: 6.1.0
NeedsCompilation: yes
Encoding: UTF-8
git_url: https://git.bioconductor.org/packages/geneXtendeR
git_branch: devel
git_last_commit: 7cf0afc
git_last_commit_date: 2025-04-15
Repository: Bioconductor 3.22
Date/Publication: 2025-06-04
Packaged: 2025-06-04 23:15:32 UTC; biocbuild
Author: Bohdan Khomtchouk [aut, cre],
  William Koehler [aut]
Built: R 4.5.0; x86_64-w64-mingw32; 2025-06-05 13:03:19 UTC; windows
Archs: x64
