Changes in version 1.3.7 UNDERLYING CHANGES - Rebuilt propertyEncoder() and onehotEncoder() to use C++ backend with encodeSequences.cpp - Rebuilt buildNetwork() via C++ integration (fastEditEdges.cpp) - Motif quantification in calculateMotif() use C++ (calculateMotif.cpp) - Reduce overall dependencies on external packages - Improved speed of generateSequences(), mutateSequences(), adjacencyMatrix(), tokenizeSequences(), geometricEncoder - Added group.by argument to getIR() - Defunct variationalSequences() - Removed keras3/tensorflow suggests/dependencies - Removed baslisk environment, python no longer required - Updated C++ backend to C++17 - Robust checks before running getIMGT() for website functioning - Removing special unicode symbols NEW FEATURES - calculateEntropy() added to calculate the positional entropy along a biological sequence - Added basic diversity metrics (exported) to support calculateEntropy() - calculateFrequency() added to calculate the positional frequency along a biological sequence - calculateMotif() added to get motif quantification of sequences - calculateGeneUsage() added for single/paired gene enumeration - Added scaleMatrix() for comprehensive scale/transformation functions - Added summaryMatrix() for fast summarization of matrix values BUGS - Fixed NT position issue with inferCDR() - Fixed generateSequence() range issue for single-length sequences - Fixed binary frequency issue in positionalEncoder() - Fixed buildNetwork() for relative thresholding returns relative value Changes in version 1.2.2 - Updated unit tests and vignette check - Converted package to basilisk from reticulate Changes in version 1.2.0 - Update version for BioConductor release Changes in version 1.0.5 UNDERLYING CHANGES - getIMGT() checks for availability of IMGT website - Expanded Unit Tests - Unit Tests and Vignette now evaluate for proper python installation overall Changes in version 1.0.4 UNDERLYING CHANGES - Optional testthat variationalSequences() evaluate presence of Keras Changes in version 1.0.3 UNDERLYING CHANGES - Drop evaluation of variationalSequences() example Changes in version 1.0.2 UNDERLYING CHANGES - Vignette includes eval of keras installation for certain chunks Changes in version 1.0.1 UNDERLYING CHANGES - Fix issue with optimizer call in variationalSequences() - Move package to keras3 - Version Bump to be consistent with Bioconductor release Changes in version 0.99.5 UNDERLYING CHANGES - Remove keras installation in vignette - Removed lazydata loading - Added @return to the data manual entries - Update stop message for propertyEncoder() - Removed set.seed from variationalSequences() - Added runnable example for variationalSequences() - Added better handling of no connection in getIMGT() - Added max.retries to getIMGT() - Updated testthat for new IMGT version Changes in version 0.99.3 UNDERLYING CHANGES - Defining python version 3.10 for keras installation Changes in version 0.99.2 UNDERLYING CHANGES - Added discrete check and install_keras() to vignette Changes in version 0.99.1 UNDERLYING CHANGES - Added warning to getIMGT() to mention IMGT license on first use - import magrittr instead of dplyr - Fixed issue with license error - Added example to positionalEncoder() - Replaced discrete calling of "es =" in vignette - Update readme to include keras based installation - added set.seed() to vignette - added introduction section to vignette with mention of other packages - removed installation section from vignette (can't add BioC instructions until accepted) - Fixed rendering issue with the vignette - Subsampled example data and removed Omniscope example - Updated testthat for formatGenes() and inferCDR() for new example data - Reduced size of test data - Minimized usage of sapply() and X:Y per BiocCheck suggestions - Modified print() messages to messages() - Add verbose parameter to turn on/off processing steps - Added links for example data formats