Changes in version 2.17.3 (2022-10-13)                 

Fixed parsing problem

    o   Fixd critial install error in R dpendency "Runit""

                 Changes in version 2.17.1 (2022-06-28)                 

Fixed parsing problem

    o   minor bugfixes

                 Changes in version 2.17.0 (2022-03-22)                 

Fixed parsing problem

    o   Fixed a parsing problem regarding the Cosmic and CCLE.
	databases

                 Changes in version 2.3.6 (2022-02-22)                  

Fixed parsing problem

    o   Fixed a parsing problem regarding the Cosmic and CCLE.
	databases

                 Changes in version 2.3.5 (2019-02-27)                  

Fixed another windows VCF parse error

    o   Fixed yet another VCF file parsing error associated with the
	VariantAnnotation R package parser.

                 Changes in version 2.3.4 (2019-02-25)                  

Fixed windows VCF parse error

    o   Uniquorn experienced an error when parsing the internal test
	vcf file on Windows systems.

                 Changes in version 2.3.3 (2019-02-22)                  

Unzip test vcf file

    o   Unzipped the tested vcf file since VarriantAnnotion parser
	failed to read zipped file in future R version 3.6

                 Changes in version 2.3.2 (2019-02-04)                  

Remove dependency

    o   Removed dependency on data.table

    o   Removed data.table import due to biocondcutor request

                 Changes in version 2.1.5 (2018-11-29)                  

Updated BiocView

    o   Updated BiocView

                 Changes in version 2.1.4 (2018-10-10)                  

Bioconductor compliance

    o   Minor bugfixes regarding the removal of CCLs

                 Changes in version 2.1.3 (2018-10-03)                  

Bioconductor compliance

    o   Minor bugfixes regarding the removal of CCLs and reference
	libraries

                 Changes in version 1.99.3 (2018-01-03)                 

Bioconductor compliance

    o   Minor modifications to comply with Bioconductor regulations

                 Changes in version 1.99.2 (2018-20-02)                 

Added RNA-seq and panel-seq capability

    o   Some more minor bugfixes

                 Changes in version 1.99.1 (2018-12-02)                 

Added RNA-seq and panel-seq capability

    o   Minor bugfixes

                 Changes in version 1.99.0 (2018-15-01)                 

Added RNA-seq and panel-seq capability

    o   Modified the package to work with large scale RNA-seq and small
	scale panel-seq data

    o   Please note that this might break custom libraries. In case of
	questions please contact the author

                 Changes in version 1.4.2 (2017-15-05)                  

Added critical scripts

    o   Added a script to parse vcf files in a non-parallelized
	fashion.

                 Changes in version 1.4.1 (2017-12-05)                  

Fixed yet another penalty function bug

    o   Fixed critical bug which disabled identifying CCLs in
	single-thread mode.

                 Changes in version 1.3.1 (2016-28-11)                  

Fixed yet another penalty function bug

    o   Fixed rather major bug that led to too high penalty scores.

                 Changes in version 1.1.3 (2016-28-11)                  

Fixed penalty function bug

    o   Fixed minor bug that led to incorrect penalty score
	calculation.

                 Changes in version 1.1.2 (2016-28-11)                  

Change of penalty function

    o   The function that measures random background-noise matches and
	calculates a threshold above the background strength has been
	updated to be more strict.

                 Changes in version 1.1.1 (2016-10-18)                  

Change of default inclusion threshold

    o   the new default inclusion weight has been set to 0.5 to
	optimally fit the new probabilistic model of version 1.0.9.

                 Changes in version 1.0.9 (2016-10-11)                  

Re-engineering of probabilistic model

    o   The likelihood to observe a mutation/ variant in a query that
	matches a reference CCL's variant has been changed. The
	likelihood was 1 / #all variants in library and is now set to #
	number of variants in reference CCL / #all variants in library

                 Changes in version 1.0.8 (2016-06-17)                  

Optimization confidence score

    o   Fixed the installation of the package

                 Changes in version 1.0.7 (2016-06-13)                  

Optimization confidence score

    o   Optimized the way confidence scores are calculated to increase
	the sensitivity and specificity of the method

                 Changes in version 1.0.6 (2016-06-05)                  

Optimization of default confidence score

    o   Adjusted default confidence score to optimal threshold

                 Changes in version 1.0.5 (2016-05-30)                  

Minor Bugfixes

    o   Fixed errors connected to adding CLs

                 Changes in version 1.0.4 (2016-05-27)                  

Introduction of confidence score

    o   Confidence score is the central threshold now

    o   Default is 3.0

    o   The score is the negative log e of the q-value

                 Changes in version 1.0.3 (2016-05-18)                  

Changes to treshold calculation

    o   Fixed error in threshold calculation

                 Changes in version 1.0.1 (2016-05-09)                  

Minor update of BED files

    o   Extended length of BED file mutations shown in the IGV

                Changes in version 0.99.16 (2016-05-04)                 

Further minor update of statistics module

    o   Further minor fixes to statistics

                Changes in version 0.99.15 (2016-05-03)                 

Minor Update of statistics

    o   Minor fixes to statistics

                Changes in version 0.99.14 (2016-05-03)                 

Major Update of statistics

    o   Replaced the absolute and relative cutoff with a p an q-value
	based on a binomial distribution

                Changes in version 0.99.13 (2016-04-08)                 

Fixed unit tests

    o   Further update test suite

                Changes in version 0.99.12 (2016-04-08)                 

Fixed unit tests

    o   Update testing suite

                Changes in version 0.99.11 (2016-04-01)                 

Fixed unit tests

    o   Fixed error in unit tests

                Changes in version 0.99.10 (2016-03-30)                 

Added Unit tests

    o   Added Unit test feature

                 Changes in version 0.99.9 (2016-03-29)                 

Improved documentation

    o   Minor documentation bugfixes.

                 Changes in version 0.99.8 (2016-03-25)                 

Fixed Bug

    o   General bugfixing.

                 Changes in version 0.99.7 (2016-03-24)                 

Fixed Bug

    o   Minor bugfix concerning output of CL identifications.

                 Changes in version 0.99.6 (2016-03-23)                 

Fixed Bug

    o   Minor bugfix concerning data parsing of CellMiner data.

                 Changes in version 0.99.5 (2016-03-22)                 

Fixed Bug

    o   Fixed a bug that lead to incorrect calculation of CoSMIC CLP CL
	mutation weights.

                 Changes in version 0.99.4 (2016-03-16)                 

Added features

    o   Minimum amount of matching mutations required for a positive
	prediction between query and training sample can now be
	manually adjusted in the 'identify_vcf_file' function using the
	parameter 'miminum_matching_mutations'

                 Changes in version 0.99.3 (2016-03-02)                 

Fixed bugs

    o   Fixed vigniette

                 Changes in version 0.99.2 (2016-03-02)                 

Fixed bugs

    o   Moved NEWS.Rd from 'Uniquorn' to 'Uniquorn/inst'

                 Changes in version 0.99.1 (2016-03-02)                 

Fixed bugs

    o   Fixed NEWS section

    o   Fixed unit testing

    o   Fixed the Vignette: replaced the github-dependent installation
	with the biocLite installation

                 Changes in version 0.99.0 (2015-01-27)                 

New features

    o   Identify cancer cell lines

    o   Show which cancer cell line are contained

    o   Show which mutations are annotated for selected cancer cell
	lines

    o   Show which mutaitons are overall included

    o   Parse cancer cell line custom data -> add your own samples and
	identify these