PolySTest

PolySTest: Detection of differentially regulated features. Combined statistical testing for data with few replicates and missing values


Bioconductor version: Release (3.20)

The complexity of high-throughput quantitative omics experiments often leads to low replicates numbers and many missing values. We implemented a new test to simultaneously consider missing values and quantitative changes, which we combined with well-performing statistical tests for high confidence detection of differentially regulated features. The package contains functions to run the test and to visualize the results.

Author: Veit Schwämmle [aut, cre]

Maintainer: Veit Schwämmle <veits at bmb.sdu.dk>

Citation (from within R, enter citation("PolySTest")):

Installation

To install this package, start R (version "4.4") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("PolySTest")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

Reference Manual PDF
NEWS Text
LICENSE Text

Details

biocViews DifferentialExpression, MassSpectrometry, Proteomics, Software
Version 0.99.6
In Bioconductor since BioC 3.20 (R-4.4) (< 6 months)
License GPL-2
Depends R (>= 4.4.0)
Imports fdrtool (>= 1.2.15), limma(>= 3.44.3), matrixStats (>= 0.57.0), qvalue(>= 2.22.0), shiny (>= 1.5.0), SummarizedExperiment(>= 1.20.0), knitr (>= 1.33), plotly (>= 4.9.4), heatmaply (>= 1.1.1), circlize (>= 0.4.12), UpSetR (>= 1.4.0), gplots (>= 3.1.1), S4Vectors(>= 0.30.0), parallel (>= 4.1.0), grDevices (>= 4.1.0), graphics (>= 4.1.0), stats (>= 4.1.0), utils (>= 4.1.0)
System Requirements
URL https://github.com/computproteomics/PolySTest
Bug Reports https://github.com/computproteomics/PolySTest/issues
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Suggests testthat (>= 3.0.0), BiocStyle
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary (x86_64)
macOS Binary (x86_64)
macOS Binary (arm64) PolySTest_0.99.6.tgz
Source Repository git clone https://git.bioconductor.org/packages/PolySTest
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/PolySTest
Bioc Package Browser https://code.bioconductor.org/browse/PolySTest/
Package Short Url https://bioconductor.org/packages/PolySTest/
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